FIFRA Scientific Advisory Panel; Notice of Public Meeting: PBPK for addressing pharmacokinetic differences between and within species

3 organizations filed 3 public comments on FIFRA Scientific Advisory Panel; Notice of Public Meeting: PBPK for addressing pharmacokinetic differences between and within species, at the Environmental Protection Agency. The comment window closed 3226d ago.

Abstract

To review PBPK or PBPK-PD models and the appropriateness of their applications in human health risk assessment, including sensitive populations. In addition, to evaluate the appropriateness of using PBPK (or PBPK-PD) models for intended risk assessment purposes, such as deriving chemical-specific extrapolation factors to replace default uncertainty factors, or estimating human points of departure for various exposure scenarios (e.g., dietary, drinking water, and worker exposures).

Commenters (3)

• Center for Biological Diversity

  1 filing · confidence 97%
• Dow ArgoSciences LLCunverified attribution

  1 filing · confidence 70%
• Oregon State University Joint Facultyunverified attribution

  1 filing · confidence 70%