Center for Biological Diversity
EPANonrulemakingEPA-HQ-OPP-2017-0180

FIFRA Scientific Advisory Panel; Notice of Public Meeting: PBPK for addressing pharmacokinetic differences between and within species

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Last modified
Apr 16, 2024
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closed 3226d ago
Center for Biological Diversity filings
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Center for Biological Diversity filed 1 comment on this docket between Sep 19, 2017 and Sep 19, 2017. 2 other organizations filed here. The comment window closed 3226d ago.

What Center for Biological Diversity filed (1)

Sep 19, 2017· Comment submitted by Nathan Donley, Ph.D., Senior Scientist, Environmental Health Program, Center for Biological Diversity (CBD)· EPA-HQ-OPP-2017-0180-0020

Filed on regulations.gov — full text not in the inline record.

Abstract

To review PBPK or PBPK-PD models and the appropriateness of their applications in human health risk assessment, including sensitive populations. In addition, to evaluate the appropriateness of using PBPK (or PBPK-PD) models for intended risk assessment purposes, such as deriving chemical-specific extrapolation factors to replace default uncertainty factors, or estimating human points of departure for various exposure scenarios (e.g., dietary, drinking water, and worker exposures).

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